Least sedating benzodiazepine
However, flumazenil does not block the effect of medicines that do not operate via this route.Interaction with other central nervous system depressants has not been observed.BECAUSE THIS FAQ IS NOT WRITTEN BY A DOCTOR, ALL ADVICE IN THIS DOCUMENT IS TO BE FOLLOWED AT YOUR OWN RISK.
Because patients with underlying hepatic impairment may experience delayed effects as described above, an extended observation period may be required.
Flumazenil reverses the central effects of benzodiazepines by means of competitive interaction at receptor level: the effects of non-benzodiazepine agonists acting via the benzodiazepine receptor, such as zopiclone, triazolopyridazine and others, are also antagonised by flumazenil.
It may therefore be used in anaesthesia and in the intensive care in the following situations: The recommended starting dose is 0.2 mg administered intravenously over 15 seconds.
If the required level of consciousness is not obtained within 60 seconds, a further dose of 0.1 mg can be injected and repeated at 60-second intervals, up to a maximum dose of 1.0 mg.
If the desired level of consciousness is not obtained after waiting an additional 45 seconds, further injection of 0.01 mg/kg may be administered (up to 0.2 mg) and repeated at 60 second intervals where necessary (a maximum of 4 times) to a maximum total dose of 0.05 mg/kg or 1 mg, whichever is lower.
The dose should be individualised based on the patient's response.
The usual dose is 0.3 to 0.6 mg, but may deviate depending on the patient's characteristics and the benzodiazepine used.
The recommended starting dose is 0.2 mg administered intravenously over 15 seconds.
THIS FAQ WAS NOT WRITTEN BY A DOCTOR OR SOMEONE WITH ANY FORM OF MEDICAL TRAINING.
THE ADVICE CONTAINED HEREIN SHOULD NOT BE SUBSTITUTED FOR THE ADVICE OF A PHYSICIAN WHO IS WELL-INFORMED IN THIS SUBJECT MATTER.
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